Hiv Protease Inhibitors Side Effects

Protease inhibitors block HIV-1 protease by occupying the active site of the protein rendering it unable to attach to the processing sites of the larger protein that it wants to cleave into mature viral particles. Some of the major side effects of protease inhibitors include the following.

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Symptoms of hyperlipidemia do not exist.

Hiv protease inhibitors side effects. Some protease inhibitors can increase this side effect. This lipodystrophy is colloquially known as Crix belly after indinavir Crixivan. Fat redistribution storing body fat in different places on your body diarrhea.

The most common side effects are HIV protease inhibitor-induced metabolic syndromes such as dyslipidemia insulin-resistance and lipodystrophylipoatrophy as well as cardiovascular and cerebrovascular diseases36 Protease inhibitor monotherapy is associated with a mild improvement in body fat distribution78 However regarding the serious adverse events of antiretroviral treatments no significant between-group differences were found between HIV protease inhibitor. 11 Most of the inhibitors are accompanied by side effects in long-term treatment. Changes in how foods taste.

HIV Infectionsdrug therapy HIV Protease Inhibitorsadverse effects Hemophilia Acomplications. Although the toxic effects of HIV protease inhibitors could result from drugdrug interactions and overdose the off-target adverse drug effects of therapeutic doses is a major concern in drug design. Side effects of hep C protease inhibitors are dizziness diarrhea fatigue headache and nausea.

Administration of HIV protease inhibitors while beneficial to AIDS patients often results in serious side effects. Hepatotoxicity is the common adverse effect of all US FDA approved HIV protease inhibitors HIV protease inhibitors induce diarrhea via different mechanisms including increased calcium-dependent chloride conductance cellular apoptosis and necrosis as well as decreased proliferation of intestinal epithelial cells. Protease inhibitors can cause a syndrome of lipodystrophy hyperlipidemia diabetes mellitus type 2 and kidney stones.

The only way to know if you have this condition is to have lab tests at least once a year. Protease inhibitors can have side effects including. Common adverse events associated with protease inhibitors include gastrointestinal side effects diarrhea nausea vomiting and metabolic complications dyslipidemia insulin resistance.

What Are the Potential Side Effects When Using Protease Inhibitors. Gastrointestinal side effects such as. Types of Protease Inhibitors Of the 26 drugs approved by the FDA for treatment of HIV 10 are protease inhibitors.

Nausea diarrhea and stomach discomfort occur in very few people. The liver helps the body break down certain medicinesincluding NNRTIs and ARVsbut the process is slower in some people than in others which can be harmful to the liver. Nausea vomiting and diarrhea are some of them.

For instance patients may develop insulin resistance that leads to type 2. Confirmed potential side effects of protease inhibitors are. In the HIV life cycle protease is an essential element for viral maturation.

Although the toxic effects of HIV protease inhibitors could result from drug drug interactions and o verdose the off-target adverse drug effects of therapeutic doses is a major concern in drug. For indinavir the side effects are kidney stones which can cause pain in the back and side. Hepatotoxicity is the medical term for damage to the liver caused by a medicine chemical or supplement and can be a side effect of some HIV medicines.

Protease inhibitors have a significant potential for interactions with certain drugs and foods. Side effects of HIV PIs are stomach discomfort diarrhea weakness and headache. Nausea vomiting diarrhea dizziness mild red itchy rash an increase or decrease in body fat high blood sugar hyperglycemia and diabetes kidney stones which can cause blood in the urine painful urination and lower back pain.

Like most medications protease inhibitors can cause side effects. Saquinavir seems to have the least side effects.

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